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Monday, April 1, 2013
Surf the Seven Channels in This Comfy Jolly Roger Chair
'G.I. Joe' commands No. 1 at box office with $41M
LOS ANGELES (AP) ? After a nine-month delay, "G.I. Joe: Retaliation" deployed to the top spot at the box office.
The action film starring Dwayne "The Rock" Johnson, Bruce Willis and Channing Tatum as the gun-toting military toys brought to life marched into the No. 1 position at the weekend box office, earning $41.2 million, according to studio estimates Sunday. "Retaliation" opened Wednesday at midnight, which helped bring its domestic total to $51.7 million.
Paramount postponed the sequel to 2009's "G.I. Joe: Rise of Cobra" last May from its original June opening date to convert the film to 3-D. The last-minute switcheroo came just weeks after "Battleship," another movie based on a Hasbro toy, sank at the box office. At that time, Paramount already began its advertising campaign for "Retaliation."
"It certainly vindicates the decision," said Don Harris, the studio's head of distribution. "Any time you make those sorts of moves, people always assume the worst. The truth is I'd seen this movie a long time ago in 2-D, and the movie worked in 2-D. It's not trying to be 'Schindler's List.' This movie is intended to be enjoyed as a big, action spectacle."
Internationally, Harris said "Retaliation" earned $80.3 million, making it the biggest international opening of the year. The film opened in 53 markets outside of the U.S. and Canada, including Russia, South Korea and Mexico.
After debuting in the top spot last weekend, the 3-D animated prehistoric comedy "The Croods" from DreamWorks Animation and 20th Century Fox slipped to the No. 2 spot with $26.5 million in its second weekend. The film features the voices of Nicolas Cage, Emma Stone and Catherine Keener as a cave family on the hunt for a new home.
Among the other new films this weekend, "Tyler Perry's Temptation" starring Jurnee Smollett-Bell and Lance Gross opened above expectations at No. 3 with $22.3 million, while the sci-fi adaptation "The Host" featuring Saoirse Ronan, Max Irons, and Jake Abel as characters from the Stephenie Meyer novel landed at No. 6 in its debut weekend with a modest $11 million.
Overall, the weekend box office was on par with last year when "The Hunger Games" continued to dominate in its second weekend of release with $58.5 million. After a slow start, Hollywood's year-to-date revenues are still 12 percent behind last year, heading into next month when summer movie season unofficially kicks off with "Iron Man 3" on May 3.
"It's getting us back on track after many weekends of down trending box office," said Paul Dergarabedian, box office analyst for Hollywood.com. "Last weekend was a turning point with the strength of 'The Croods' and 'Olympus Has Fallen' doing better than expected. We're heading toward the summer movie season on solid footing. It's been a tough year so far."
Estimated ticket sales for Friday through Sunday at U.S. and Canadian theaters, according to Hollywood.com. Where available, latest international numbers are included. Final domestic figures will be released Monday.
1. "G.I. Joe: Retaliation," $41.2 million ($80.3 million international).
2. "The Croods," $26.5 million ($52.5 million international).
3. "Tyler Perry's Temptation," $22.3 million.
4. "Olympus Has Fallen," $14 million.
5. "Oz the Great and Powerful," $11.6 million ($22.2 million international).
6. "The Host," $11 million ($6 million international).
7. "The Call," $4.8 million.
8. "Admission," $3.2 million.
9. "Spring Breakers," $2.7 million.
10. "The Incredible Burt Wonderstone," $1.3 million.
___
Estimated weekend ticket sales at international theaters (excluding the U.S. and Canada) for films distributed overseas by Hollywood studios, according to Rentrak:
1. "G.I. Joe: Retaliation," $80.3 million.
2. "The Croods," $52.5 million.
3. "Jack the Giant Slayer," $25.2 million.
4. "Oz the Great and Powerful," $22.2 million.
5. "Dragon Ball Z: Kami to Kami," $7 million.
6. "The Host," $6 million.
7. "Identity Thief," $5.5 million.
8. "Wreck-It Ralph," $4 million.
9. "A Good Day to Die Hard," $3.6 million.
10. "Hansel and Gretel: Witch Hunters," $3.3 million.
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Online:
http://www.hollywood.com
http://www.rentrak.com
___
Universal and Focus are owned by NBC Universal, a unit of Comcast Corp.; Sony, Columbia, Sony Screen Gems and Sony Pictures Classics are units of Sony Corp.; Paramount is owned by Viacom Inc.; Disney, Pixar and Marvel are owned by The Walt Disney Co.; Miramax is owned by Filmyard Holdings LLC; 20th Century Fox and Fox Searchlight are owned by News Corp.; Warner Bros. and New Line are units of Time Warner Inc.; MGM is owned by a group of former creditors including Highland Capital, Anchorage Advisors and Carl Icahn; Lionsgate is owned by Lions Gate Entertainment Corp.; IFC is owned by AMC Networks Inc.; Rogue is owned by Relativity Media LLC.
___
Follow AP Entertainment Writer Derrik J. Lang on Twitter at http://www.twitter.com/derrikjlang.
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Amazon Cloud Drive tacks on file syncing, flexes its digital storage muscle
After nearly a year on the market, Amazon has finally blessed its Cloud Drive apps for Windows and Mac with a file syncing folder. Starting today, users can access their documents, music and photos across multiple computers -- a feature that we've seen from the likes of Google Drive, Dropbox and SkyDrive for quite some time. While this feature is far from groundbreaking, it does manage to make Amazon's service a respectable alternative to cloud storage's reigning heavy hitters. Toss in its 5GB of free storage and Cloud Drive could become a worthy contender for those who are looking for a new or additional place to house their digital collections.
Filed under: Storage, Software, Amazon
Via: The Verge
Source: Amazon
Source: http://www.engadget.com/2013/04/01/amazon-cloud-drive-file-syncing/
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Create a Modern Concrete Stool for $5
You can check out the video above for the full walkthrough, but essentially you're just putting a few inches of wet concrete in a bucket for the stool's seat, then sticking in some thick wooden dowel rods for the legs. Once the concrete sets, you can pull it out of the bucket and smooth it down for a modern, industrial-style stool. The stool shown in the video is pretty short, but you could easily just cut the dowels longer if you need a proper barstool. If you don't have a bar at home, this would also look right at home at a workbench in your garage.
How to Make a Sweet $5 Bar Stool Using Wooden Dowels & Concrete | WonderHowTo
Source: http://feeds.gawker.com/~r/lifehacker/full/~3/hY87VsNOFRI/create-a-modern-concrete-stool-for-5
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New clues about how amyotrophic lateral sclerosis (ALS) develops
Mar. 31, 2013 ? Johns Hopkins scientists say they have evidence from animal studies that a type of central nervous system cell other than motor neurons plays a fundamental role in the development of amyotrophic lateral sclerosis (ALS), a fatal degenerative disease. The discovery holds promise, they say, for identifying new targets for interrupting the disease's progress.
In a study described online in Nature Neuroscience, the researchers found that, in mice bred with a gene mutation that causes human ALS, dramatic changes occurred in oligodendrocytes -- cells that create insulation for the nerves of the central nervous system -- long before the first physical symptoms of the disease appeared. Oligodendrocytes located near motor neurons -- cells that govern movement -- died off at very high rates, and new ones regenerated in their place were inferior and unhealthy.
The researchers also found, to their surprise, that suppressing an ALS-causing gene in oligodendrocytes of mice bred with the disease -- while still allowing the gene to remain in the motor neurons -- profoundly delayed the onset of ALS. It also prolonged survival of these mice by more than three months, a long time in the life span of a mouse. These observations suggest that oligodendrocytes play a very significant role in the early stage of the disease.
"The abnormalities in oligodendrocytes appear to be having a negative impact on the survival of motor neurons," says Dwight E. Bergles, Ph.D., a co-author and a professor of neuroscience at the Johns Hopkins University School of Medicine. "The motor neurons seem to be dependent on healthy oligodendrocytes for survival, something we didn't appreciate before."
"These findings teach us that cells we never thought had a role in ALS not only are involved but also clearly contribute to the onset of the disease," says co-author Jeffrey D. Rothstein, M.D., Ph.D., a professor of neurology at Johns Hopkins and director of the Johns Hopkins Medicine Brain Science Institute.
Scientists have long believed that oligodendrocytes functioned only as structural elements of the central nervous system. They wrap around nerves, making up the myelin sheath that provides the "insulation" that allows nerve signals to be transmitted rapidly and efficiently. However, Rothstein and others recently discovered that oligodendrocytes also deliver essential nutrients to neurons, and that most neurons need this support to survive.
The Johns Hopkins team of Bergles and Rothstein published a paper in 2010 that described in mice with ALS an unexpected massive proliferation of oligodendrocyte progenitor cells in the spinal cord's motor neurons, and that these progenitors were being mobilized to make new oligodendrocytes. The researchers believed that these cells were multiplying because of an injury to oligodendrocytes, but they weren't sure what was happening. Using a genetic method of tracking the fate of oligodendrocytes, in the new study, the researchers found that cells present in young mice with ALS were dying off at an increasing rate in concert with advancing disease. Moreover, the development of the newly formed oligodendrocytes was stalled and they were not able to provide motor neurons with a needed source of cell nutrients.
To determine whether the changes to the oligodendrocytes were just a side effect of the death of motor neurons, the scientists used a poison to kill motor neurons in the ALS mice and found no response from the progenitors, suggesting, says Rothstein, that it is the mutant ALS gene that is damaging oligodendrocytes directly.
Meanwhile, in separate experiments, the researchers found similar changes in samples of tissues from the brains of 35 people who died of ALS. Rothstein says it may be possible to see those changes early on in the disease and use MRI technology to follow progression.
"If our research is confirmed, perhaps we can start looking at ALS patients in a different way, looking for damage to oligodendrocytes as a marker for disease progression," Rothstein says. "This could not only lead to new treatment targets but also help us to monitor whether the treatments we offer are actually working."
ALS, also known as Lou Gehrig's disease, named for the Yankee baseball great who died from it, affects nerve cells in the brain and spinal cord that control voluntary muscle movement. The nerve cells waste away or die, and can no longer send messages to muscles, eventually leading to muscle weakening, twitching and an inability to move the arms, legs and body. Onset is typically around age 50 and death often occurs within three to five years of diagnosis. Some 10 percent of cases are hereditary.
There is no cure for ALS and there is only one FDA-approved drug treatment, which has just a small effect in slowing disease progression and increasing survival.
Even though myelin loss has not previously been thought to occur in the gray matter, a region in the brain where neurons process information, the researchers in the new study found in ALS patients a significant loss of myelin in one of every three samples of human tissue taken from the brain's gray matter, suggesting that the oligodendrocytes were abnormal. It isn't clear if the oligodendrocytes that form this myelin in the gray matter play a different role than in white matter -- the region in the brain where signals are relayed.
The findings further suggest that clues to the treatment of other diseases long believed to be focused in the brain's gray matter -- such as Alzheimer's disease, Huntington's disease and Parkinson's disease -- may be informed by studies of diseases of the white matter, such as multiple sclerosis (MS). Bergles says ALS and MS researchers never really thought their diseases had much in common before.
Oligodendrocytes have been under intense scrutiny in MS, Bergles says. In MS, the disease over time can transform from a remitting-relapsing form -- in which myelin is attacked but then is regenerated when existing progenitors create new oligodendrocytes to re-form myelin -- to a more chronic stage in which oligodendrocytes are no longer regenerated. MS researchers are working to identify new ways to induce the creation of new oligodendrocytes and improve their survival. "It's possible that we may be able to dovetail with some of the same therapeutics to slow the progression of ALS," Bergles says.
Other Johns Hopkins researchers involved in the study include Shin H. Kang, Ph.D.; Ying Li, Ph.D.; Ileana Lorenzini, M.S.; and Lyle Ostrow, M.D., Ph.D.
This research was supported by grants from the National Institutes of Health's National Institute of Neurological Disorders and Stroke (NS 051509), the ALS Association, P2ALS, the Robert Packard Center for ALS Research at Johns Hopkins and the Brain Science Institute.
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The above story is reprinted from materials provided by Johns Hopkins Medicine, via Newswise.
Note: Materials may be edited for content and length. For further information, please contact the source cited above.
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Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.
Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/oRzxChOcUuo/130331165048.htm
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Travel & Leisure Blog's: How To Get Good Accommodations On ...
By Carla Rossouw
When travelling, one of the most important things that you need to plan is the accommodation. You need to make sure that you have a comfortable place to sleep at in every country that you visit. Travel tours are exciting but they should also be relaxing.Consider your budget. You cannot book any place you want especially if your budget is limited. It is better if you first fix your budget then browse all the options that fall into it. If you are a backpacker, you can find cheap places but it may not have everything that you need. If you are on a luxury travel, you can choose hotels that are complete with all the amenities however it might be pricier.
Amenities and facilities are also deciding factors when choosing a hotel. Does the hotel have the things that you need? If you feel relaxed when watching TV, you should get a room that provides television. If you love surfing the internet or if you need to check e-mails every day, you should book a hotel with internet service. It will be better if the internet service is a wireless one so you would not need to attach some cables. Wi-Fi will also allow you to connect to the internet using your gadgets.
Always read hotel reviews. Those are the feedbacks of past clients around the hotels they've visited. The positive thing about hotel reviews is they offer factual and almost accurate details about the present status from the hotel. Some share pictures which means you would observe how your accommodation really appears like. The issue with hotel websites is they are occasionally fuelling their ads. They publish great pictures that aren't the same as the things they really offer. By reading through hotel reviews, you will be aware the reality. Additionally, you will know about other main reasons for example safety, hygiene and customer support.
Consider the location as much as possible. The worst thing that could happen to you is to have a hotel that is too far off from civilization. The hotel might be cheap but you will have to travel for a long time before you can reach the city. Not only will you waste time but also money. Make sure that the hotel you are going to book is strategically situated. It should be near establishments and if possible, near the airport. This way, you will not have a hard time adjusting your time to reach the airport on time. In addition, you should make sure that there are public transportations available near your hotel.
Added services are great deals. Before you choose a place, you should ask the receptionist for other deals that they may be offering. If you can get complimentary breakfast or free shuttle service around the city, that would be great. Some hotels may even offer free valet services to and from airports for guests who are coming and departing the country.
Finding an accommodation is easy because there are a lot of choices. However, you should always be wise by considering all important things.
About the Author:
Learn more about travel guiding, stop by Carla's site where you can find everything about Travel blog and Hotel Reviews to help you choose the best place to stay in during your vacation.
Source: http://travel-leisure-blogs.blogspot.com/2013/03/how-to-get-good-accommodations-on.html
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Italy president denies to resign, will stay to deal with crisis
By Giselda Vagnoni
ROME (Reuters) - Italian President Giorgio Napolitano on Saturday ruled out standing down to make way for new parliamentary elections after the failure of attempts to form a government this week, saying he would stay in place until the very end of his mandate in May.
Earlier, all of Italy's main newspapers said Napolitano, whose term ends on May 15, was considering stepping down to get around constitutional provisions which prevent a president dissolving parliament and calling elections in the final months of his mandate.
But the 87-year-old head of state told reporters he would continue his efforts to break the deadlock since elections last month that left no single group with enough power to govern.
"I will continue until the last day of my mandate to do as my sense of national responsibility suggests, without hiding from the country the difficulties that I am still facing," he told reporters at his Quirinale palace.
He said he would ask two small groups of experts to formulate proposals for institutional and economic reforms that could be supported by all political parties.
Napolitano met leaders of the main parties on Friday to try to find a way out of the stalemate, which has raised fears of prolonged uncertainty in the euro zone's third-largest economy.
However with all of the three main groups in parliament clinging to entrenched positions that have prevented a majority being formed in parliament, hopes of a solution that would avoid a new snap election have faded.
Center-left leader Pier Luigi Bersani, whose party controls the lower house but does not have a majority in the Senate, failed to win enough support to form a government from any of the other parties during a week of talks.
He rejected demands by center-right leader Silvio Berlusconi for a cross-party coalition deal that would give the scandal-plagued former prime minister a share in power and the right to decide Napolitano's successor.
Both Berlusconi's group and the populist 5-Star Movement led by ex-comic Beppe Grillo have also ruled out supporting a new technocrat government like the one led by outgoing Prime Minister Mario Monti, blocking what appears to be the only other option.
(Writing by James Mackenzie; editing by Barry Moody)
Source: http://news.yahoo.com/italy-president-could-resign-allow-election-source-083108238--business.html
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